Peer-reviewed veterinary case report
A mouse model of bilateral acute inner-ear (labyrinthine) injury with vestibular involvement reveals functional, behavioral, and histological correlates of vestibular compensation.
- Journal:
- Neuroscience research
- Year:
- 2025
- Authors:
- Xie, Jingyi et al.
- Affiliation:
- The Second Affiliated Hospital of Xi'an Jiaotong University · China
Abstract
Bilateral vestibular dysfunction disrupts balance and spatial orientation, yet mechanisms of injury and compensation remain incompletely defined. We established a mouse model of bilateral acute inner-ear (labyrinthine) injury with vestibular involvement by sequentially incising the round and oval windows, and evaluate auditory brainstem responses (ABR), vestibular sensory-evoked potentials (VsEP), behavior, and histology across postoperative days 1-28. Threshold elevations and behavioral impairment peaked on day 3, with hair-cell degeneration most prominent early and partial morphological recovery by day 28. These findings delineate the acute injury phase and early stabilization, providing a platform to study vestibular repair and functional recovery.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41213332/