Peer-reviewed veterinary case report
A mouse model of chronic cerebral hypoperfusion characterizing features of vascular cognitive impairment.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2014
- Authors:
- Ihara, Masafumi et al.
- Affiliation:
- Department of Stroke and Cerebrovascular Diseases · Japan
Abstract
Vascular dementia or vascular cognitive impairment occurs as a result of persistently compromised blood flow to the brain and represents the second most common type of dementia after Alzheimer's disease. In order to investigate its underlying mechanisms, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. This mouse model provides a unique platform to investigate the mechanisms of angiogenesis following chronic cerebral hypoperfusion and to explore potential drugs or cell therapies designed to enhance angiogenesis as a preclinical step toward developing novel treatments for dementia of vascular origin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24510857/