Peer-reviewed veterinary case report
A mouse model to identify cooperating signaling pathways in cancer.
- Journal:
- Nature methods
- Year:
- 2012
- Authors:
- Musteanu, Monica et al.
- Affiliation:
- Ludwig Boltzmann Institute for Cancer Research
Abstract
We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22863881/