Peer-reviewed veterinary case report
New bladder stone found in 4 cats and 1 dog
By Frank, Adrian et al.·Published in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2002·Department of Clinical Chemistry·View original on PubMed →
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Original publication title: A new urolith in four cats and a dog: composition and crystal structure.
Plain-English summary
A 5-year-old collie was found to have a bladder stone, which is a type of mineral buildup that can cause serious health issues. This stone was made up of potassium, magnesium, and phosphorus, and it was identified through chemical analysis. The presence of this unusual stone may be linked to a genetic issue affecting an enzyme that helps break down certain minerals. Treatment options typically involve surgical removal of the stone and addressing any underlying health concerns to prevent future occurrences.
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Abstract
A previously unreported urolith is presented. The concrement was found in the bladder of four Persian cats and one collie dog. It contained potassium, magnesium and phosphorus, all determined by chemical analysis. The infrared spectrum of the X-ray-dense urolith displayed absorption bands in the phosphate region. A single absorption maximum at 930 cm(-1) indicated the presence of inorganic pyrophosphate. A single crystal structure determination of the urolith has been performed. The results obtained are consistent with the formula [K(1.0)Mg(1.5)](4+)[P(2)O(7)](4-.)(H(2)O)(5), which corresponds to 11.5% K, 10.7% Mg and 18.2% P. The structure contains negatively charged slabs of composition MgP(2)O(7) small middle dot(H(2)O)(2)(2-)alternating with positively charged, hydrated Mg(2+) and K(+) ions. The observed P(2)O(7) is that of a distorted eclipsed syn conformation, which is the most common geometry in the solid state according to a statistical analysis of known structural data. A simple numerical descriptor has been derived, classifying observed X(2)O(7) conformations. It is suggested that some genetic enzymatic dysfunction of pyrophosphate-hydrolysing alkaline phosphatase might cause the formation of this unusual urolith.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11941501/