Peer-reviewed veterinary case report
A novel and efficient model of coronary artery ligation in the mouse.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2013
- Authors:
- Gao, Erhe & Koch, Walter J
- Affiliation:
- Temple University School of Medicine · United States
- Species:
- rodent
Abstract
Coronary artery ligation to induce myocardial infarction (MI) and ischemia/reperfusion (I/R) injury in mice is typically performed by an invasive and time-consuming approach that requires ventilation and a full thoracotomy (classical method), often resulting in extensive tissue damage and high mortality. Here, we describe a novel and rapid surgical method to induce MI that does not require ventilation. This method is much more efficient and safer than the classical method of MI and I/R injury.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24029943/