Peer-reviewed veterinary case report
A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection.
- Journal:
- Microbiology and immunology
- Year:
- 2005
- Authors:
- Mun, Hye-Seong et al.
- Affiliation:
- Department of Infection and Host Defense · Japan
- Species:
- rodent
Abstract
Irradiation treatment enhanced resistance of C57BL/6, but not BALB/c against Toxoplasma gondii infection. Six Gy-irradiated (IR) C57BL/6 recipients of B-2 cells from T. gondii-infected C57BL/6 died after infection. B-2 suppressor cells from infected C57BL/6 enhanced production of IL-4 and IL-10 in peritoneal exudate cells (PECs), and down-regulated NO release in peritoneal macrophages after infection. On the other hand, B-2 suppressor cells were not detected in a strain, BALB/c, resistant against infection. These data indicated that irradiation-sensitive B-2 cells regulated susceptibility/resistance in mice against T. gondii infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16172540/