Peer-reviewed veterinary case report
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2013
- Authors:
- Hoyt, Scott B et al.
- Affiliation:
- Department of Medicinal Chemistry · United States
- Species:
- rodent
Abstract
A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23652221/