Peer-reviewed veterinary case report
New bocavirus found in dog liver with severe illness
By Li, Linlin et al.·Published in Virology journal·2013·Blood Systems Research Institute, United States·View original on PubMed →
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Original publication title: A novel bocavirus in canine liver.
- Species:
- dog
Plain-English summary
A dog with severe vomiting and diarrhea was found to have a new type of bocavirus in its liver after suffering from serious health issues like kidney failure and inflammation. This virus, named Canine bocavirus 3, is different from previously known bocaviruses that affect dogs. While the exact role of this new virus in the dog's illness is still unclear, it highlights the potential for new viral infections in pets. Further research is needed to understand how this virus may impact dog health.
People also search for: dog vomiting diarrhea · new dog virus liver · bocavirus in dogs · dog kidney failure causes
Abstract
BACKGROUND: Bocaviruses are classified as a genus within the Parvoviridae family of single-stranded DNA viruses and are pathogenic in some mammalian species. Two species have been previously reported in dogs, minute virus of canines (MVC), associated with neonatal diseases and fertility disorders; and Canine bocavirus (CBoV), associated with respiratory disease. FINDINGS: In this study using deep sequencing of enriched viral particles from the liver of a dog with severe hemorrhagic gastroenteritis, necrotizing vasculitis, granulomatous lymphadenitis and anuric renal failure, we identified and characterized a novel bocavirus we named Canine bocavirus 3 (CnBoV3). The three major ORFs of CnBoV3 (NS1, NP1 and VP1) shared less than 60% aa identity with those of other bocaviruses qualifying it as a novel species based on ICTV criteria. Inverse PCR showed the presence of concatemerized or circular forms of the genome in liver. CONCLUSIONS: We genetically characterized a bocavirus in a dog liver that is highly distinct from prior canine bocaviruses found in respiratory and fecal samples. Its role in this animal's complex disease remains to be determined.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23402347/