Peer-reviewed veterinary case report
Stroke caused by artery blockage in beagle dogs studied with new model
By Liu, Sheng et al.·Published in Journal of neuroscience methods·2012·Department of Radiology, China·View original on PubMed →
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Original publication title: A novel embolic stroke model resembling lacunar infarction following proximal middle cerebral artery occlusion in beagle dogs.
- Species:
- dog
Plain-English summary
Researchers have developed a new model to study a type of stroke called lacunar infarction, which happens when small areas of the brain lose blood flow. They used eight beagle dogs and blocked a specific artery in the brain to create this condition. By taking images of the dogs' brains over six hours, they found small areas of damage that matched what is seen in human lacunar strokes. This study shows that blood clots can indeed cause these types of strokes in dogs, helping to better understand the condition.
Abstract
It is estimated that lacunar infarcts account for 25% of all ischemic strokes, but its exact etiology is still on debating. The existing controversies include whether the embolisms can indeed cause lacunar stroke in humans or animal models. We hypothesized that lacunar infarction can be induced by the proximal middle cerebral artery (MCA) segmental occlusion involving the orifices of lenticulostriate arteries in animal models, which have abundant distal cerebral collateral anastomosis. Our work here establishes a proximal MCA occlusion model using thrombi (autologous blood clots about 1.7 mm in diameter and 5 mm in length) in 8 beagle dogs, evaluates the progression of ischemic lesions at 30 min interval within 6 h after embolization using the diffusion weighted imaging (DWI), and discusses the potential mechanisms of lacunar infarction. Our results indicate that the left proximal MCAs can be successfully occluded in all dogs using interventional single-thrombus method. The small solitary or multiple ischemic lesions shown in DWI were observed in the deep brain area, with the mean detecting time of 1.21 ± 0.45 h using DWI and diameter of 6.62 ± 0.60mm in 6h-DWI after procedure. In conclusion, our method established an ischemic model which can recapitulate the radiologic and histologic changes in lacunar infarcts, suggesting that emboli can cause lacunar infarcts in animal model.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22722089/