Peer-reviewed veterinary case report
A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice.
- Journal:
- Biological & pharmaceutical bulletin
- Year:
- 2004
- Authors:
- Kohno, Takeyuki et al.
- Affiliation:
- Department of Environmental Health Sciences · Japan
- Species:
- rodent
Abstract
Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15340225/