Peer-reviewed veterinary case report
Schnauzer puppy with chronic breathing infections linked to NAT10
By B. Hedgespeth et al.·Published in Journal of Veterinary Internal Medicine·2021·View original on Semantic Scholar →
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Original publication title: A novel missense mutation of the NAT10 gene in a juvenile Schnauzer dog with chronic respiratory tract infections
- Species:
- dog
Plain-English summary
An 18-month-old male Schnauzer was brought in for chronic respiratory infections that didn't improve with various antibiotics and steroids. The dog also experienced ongoing vomiting and diarrhea that didn't respond well to diet changes or medications. Sadly, despite supportive care, the dog had to be euthanized at 20 months due to these persistent health issues. Genetic testing revealed a mutation in the NAT10 gene, which is linked to ciliary development and may explain the dog's chronic respiratory problems. This case suggests a potential genetic cause for similar respiratory issues in dogs.
People also search for: Schnauzer respiratory infections treatment · dog vomiting and diarrhea causes · NAT10 gene mutation in dogs
Abstract
Abstract An 18‐month‐old intact male Schnauzer dog was evaluated for chronic, lifelong respiratory tract infections that were unresponsive to administration of a variety of antibiotics and corticosteroids. The dog developed persistent vomiting and diarrhea around 1 year of age that was minimally responsive to diet change, antibiotics, and corticosteroids. Despite supportive care, the dog was ultimately euthanized at 20 months of age due to persistent respiratory and gastrointestinal disease. Whole genome sequencing discovered a deleterious missense A/C mutation within the NAT10 gene, a gene essential for microtubule acetylation, appropriate ciliary development, and cytokinesis. Pipeline analysis of the genomes of 579 dogs from 55 breeds did not detect this mutation. Though never described in veterinary medicine, NAT10 mutation occurs in humans with ciliary aplasia, suggesting a pathophysiological mechanism for this dog and highlighting an associated mutation or possible novel genetic cause of chronic respiratory infections in dogs.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/33755251