Peer-reviewed veterinary case report
A novel model for post-transplant obliterative airway disease reveals angiogenesis from the pulmonary circulation.
- Journal:
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Year:
- 2005
- Authors:
- Dutly, Andre E et al.
- Affiliation:
- Toronto General Hospital Research Institute · Canada
Abstract
We present a novel animal model for post-transplant obliterative airway disease in which the donor trachea is implanted into the recipient's lung parenchyma. Although this procedure is technically more challenging than the heterotopic model of implantation into a subcutaneous pouch, it has several important advantages some of which are the appropriate local environment and the possibility of local immunosuppressive therapy after transtracheal gene, cell or drug delivery. This model has revealed new insights into angiogenic potential of the pulmonary circulation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15643984/