Peer-reviewed veterinary case report
New canine adenovirus linked to deadly infectious hepatitis in dogs
By Wong, Magdelene et al.·Published in Viral immunology·2017·1 School of Animal and Veterinary Science, Australia·View original on PubMed →
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Original publication title: A Novel Recombinant Canine Adenovirus Type 1 Detected from Acute Lethal Cases of Infectious Canine Hepatitis.
- Species:
- dog
Plain-English summary
Two dogs with infectious canine hepatitis (ICH) sadly died after showing severe liver damage and bleeding. Tests revealed that the virus affecting them was a new type of canine adenovirus, which may have resulted from a mix between two known strains. This new virus could explain why some vaccines didn't work as expected or why the disease was more severe in these cases. Unfortunately, the dogs did not survive, highlighting the importance of monitoring for new strains of this virus.
People also search for: dog hepatitis symptoms · canine adenovirus vaccine failure · why did my dog die suddenly
Abstract
In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centrilobular to panlobular necrohemorrhagic hepatitis and the development of disseminated intravascular coagulation in the terminal stages of disease. Comparison of partial genome sequences revealed that although these newly detected viruses mainly had CAdV-1 genome characteristics, their pVIII gene was more similar to that of CAdV-2. This likely suggests that a recombination has occurred between CAdV-1 and CAdV-2, which possibly explains the cause of vaccine failure or increased virulence of the virus in the observed ICH cases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28426340/