A peri-wound wearable system for dual-modal monitoring and management of healing dynamics.

Abstract

Monitoring wound physiological conditions and implementing timely intervention are crucial for preventing chronic transformation. While flexible bioelectronics offer the potential for real-time wound assessment, existing technologies predominantly rely on wound-contact measurements, which may disrupt the fragile wound microenvironment and even pose infection risks. Here we present a peri-wound wearable system combined impedance and oxygen saturation (SpO) monitoring, enabling a non-contact, dual-modal evaluation of the healing process through tissue regeneration status and microcirculatory dynamics. The system incorporates a bio-adhesive hydrogel with hydration-maintaining design for long-term impedance sensing and a perovskite-based photodetector for localized SpOquantification, both with distinct relevance to wound structural remodeling and functional recovery. In mouse models of excisional, burn and diabetic wounds, experimental results confirmed that the integrated system accurately tracks the healing trajectory, and significantly accelerates wound closure when coupled with tailored electrical stimulation. This peri-wound wearable system achieves concurrent structural-functional evaluation and treatment while avoiding potential disturbance to fragile tissue, offering an innovative paradigm for comprehensive wound management.