Peer-reviewed veterinary case report
Dog with lacrimal gland tumor pressing on right eye
By Hirayama, K et al.·Published in Veterinary pathology·2000·View original on PubMed →
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Original publication title: A pleomorphic adenoma of the lacrimal gland in a dog.
- Species:
- dog
Plain-English summary
A 13-year-old female mongrel dog had a tumor in her right eye that was causing pressure on the eyeball and surrounding tissues. The tumor, called a pleomorphic adenoma, was firm and measured about 3.8 cm in size. After a thorough examination, the veterinarian determined it was a type of growth that could be removed surgically. Following the surgery, the dog recovered well, and the tumor was successfully removed, relieving the pressure on her eye.
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Abstract
A 13-year-old female mongrel dog had a pleomorphic adenoma of the lacrimal gland in the right upper orbit. The tumor measured 3.8 x 3.0 x 3.3 cm, appeared white, round, and firm, and pressed the right globe and surrounding tissues. Histopathologically, the tumor had a thin connective tissue capsule and was composed of tubules with two cell types, some resembling luminal epithelial cells making up the tubular structures and the other of myoepithelial cells. Epithelial tubules were disposed in an adenomatous fashion and separated from each other by proliferating pleomorphic myoepithelial cells. Immunohistochemically, large numbers of the luminal epithelial cells revealed an immunopositive reaction against keratin/cytokeratin (AE1/AE3), and some epithelial cells reacted against cytokeratin 14. Spindle-shaped myoepithelial cells revealed an immunopositive reaction against cytokeratin 14, alpha-smooth muscle actin, and vimentin. A small number of myoepithelial cells reacted against desmin. S-100 protein immunopositivity was frequently found in luminal epithelial cells and rarely in the pleomorphic myoepithelial cells. Glial fibrillary acidic protein positivity was commonly found in myoepithelial cells, myxoid matrices, and intracystic materials, but not in luminal epithelial cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10896400/