Peer-reviewed veterinary case report
How often do dogs have reactions to blood transfusions
By Hall, Georgina B F et al.·Published in Journal of veterinary internal medicine·2024·The Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs.
- Species:
- dog
Plain-English summary
A study looked at dogs receiving blood transfusions and found that about 9% experienced reactions, especially when given packed red blood cells (pRBCs) that were older than 28 days. The most common reactions included fever and allergic responses. The risk of these reactions increased with higher doses of pRBCs and older blood. This information is important for veterinarians to consider when deciding on blood transfusions for dogs, as using fresher blood and monitoring the dose can help reduce the chances of adverse reactions.
People also search for: dog blood transfusion reactions · why is my dog having a fever after blood transfusion · packed red blood cells for dogs
Abstract
BACKGROUND: Reported incidence of blood transfusion reactions (TR) varies greatly. OBJECTIVE: To prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors associated with TRs. ANIMALS: Dogs (n = 858) administered allogenic blood products (n = 1542) between March and November 2022. METHODS: Prospective, multicenter surveillance study occurring in referral hospitals in the United States, United Kingdom, and Australia recording TRs in dogs administered blood products as defined by the consensus guidelines published by The Association of Veterinary Hematology and Transfusion Medicine in 2021. RESULTS: The incidence of acute TR was 8.9% (95% CI 7.0-11.1) for packed red blood cells (pRBCs) and 4.5% (95% CI 2.9-6.6) for plasma products. The most frequently reported TRs were febrile nonhemolytic TRs (FNHTR; 4%, 95% CI 2.8-5.5) when administering pRBCs and allergic TRs (3.2%, 95% CI 1.80-5.10) when administering plasma products. A higher dose of pRBC (adjusted odds ratio [aOR] 1.04 [95% CI 1.00-1.08]) was associated with a higher odds of TR. Administration of pRBCs stored for longer than 28 days was associated with higher odds of FNHTR (aOR 4.10 [95% CI 1.58-10.65]) and acute hemolytic TR (AHTR; OR 15.2 [95% CI 3.35-68.70]) when compared with pRBCs stored for 14 days or fewer. Leukoreduction of pRBC was not associated with lower odds of developing a TR (OR 1.47 [95% CI 0.89-2.42]). CONCLUSIONS AND CLINICAL IMPORTANCE: Clinicians should be mindful of the age and dose of pRBC prescribed to dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39239720/