Peer-reviewed veterinary case report
Effect of Enterococcus faecium probiotic on dogs with food-responsive
By S. Schmitz et al.·Published in Journal of Veterinary Internal Medicine·2015·View original on Semantic Scholar →
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Original publication title: A Prospective, Randomized, Blinded, Placebo‐Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food‐Responsive Chronic Enteropathy
- Species:
- dog
Plain-English summary
A group of dogs with food-responsive chronic enteropathy (a type of intestinal inflammation) was given either a probiotic supplement containing Enterococcus faecium or a placebo for six weeks while on a special diet. Out of 45 dogs, only 12 completed the study, and the results showed no significant difference in improvement between the two groups. However, all dogs responded well to the standard dietary treatment, suggesting that the diet alone was effective. The study couldn't determine if the probiotic had any additional benefits due to the small number of dogs that finished the trial.
People also search for: dog chronic diarrhea treatment · probiotics for dog intestinal issues · food-responsive enteropathy in dogs
Abstract
Background Canine chronic enteropathies (CE) are believed to be caused by an aberrant immune response towards the intestinal microbiome. Administration of probiotics can alleviate colitis in people. In vitro effects of the probiotic Enterococcus faecium NCIMB 10415 E1707 (EF) previously have been evaluated using canine cells (e.g., whole blood, intestinal biopsies), but data on in vivo efficacy are lacking. Hypothesis/Objectives Administration of EF to dogs with food‐responsive CE will improve clinical outcome and decrease the intestinal inflammatory profile. Animals Dogs diagnosed with CE were prospectively recruited to receive a hydrolyzed elimination diet plus either a synbiotic product containing EF or placebo for 6 weeks. Both veterinary staff and owners were blinded to the treatment. Methods Clinical severity index (CCECAI), clinicopathological data and gene expression using intestinal biopsies (TLR2/4/5/9, IL‐17A, IL‐22, IL‐23p19, RORC, IL‐2, IL‐12p35, TNFα, IL‐4, IFNy, IL‐10, TGFβ, IL‐1β, IL‐18, NLRP3, casp‐1, TFF1, TFF3 and PPARy) before and after 6 weeks of treatment were analyzed using linear mixed modeling. Results Of the 45 cases recruited, 12 finished the clinical trial. Seven received the synbiotic and 5 the placebo product. There was no difference between groups or treatments regarding clinical efficacy, histology scores or expression of any of the investigated genes. Conclusions and clinical importance Standard dietary treatment induced rapid clinical response in all cases. Because the study was underpowered, it was not possible to determine whether or not EF had an additional effect within the time period of 6 weeks.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/25776251