Peer-reviewed veterinary case report
Bedinvetmab monthly injection reduces osteoarthritis pain in dogs
By Michels, Gina M et al.·Published in Veterinary anaesthesia and analgesia·2023·Veterinary Medicine Research and Development, United States·View original on PubMed →
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Original publication title: A prospective, randomized, double-blind, placebo-controlled multisite, parallel-group field study in dogs with osteoarthritis conducted in the United States of America evaluating bedinvetmab, a canine anti-nerve growth factor monoclonal antibody.
- Species:
- dog
Plain-English summary
A group of dogs with osteoarthritis were given either a new treatment called bedinvetmab or a placebo to see which helped relieve their pain. After a month, the dogs receiving bedinvetmab showed a significant improvement in their pain levels compared to those on the placebo, with nearly half of the treated dogs reporting less pain. The treatment was given as an injection once a month, and it continued to help the dogs feel better over time. Overall, bedinvetmab was found to be safe and effective for managing pain related to osteoarthritis in dogs.
People also search for: dog osteoarthritis treatment · bedinvetmab for dogs · how to relieve dog joint pain
Abstract
OBJECTIVE: Bedinvetmab, a fully canine anti-nerve growth factor monoclonal antibody, was evaluated in dogs for control of osteoarthritis-related pain in a study conducted to support registration in the USA. STUDY DESIGN: Randomized, double-blind, placebo-controlled, multicenter, parallel-group study. ANIMALS: General practice client-owned dogs with osteoarthritis (n = 272). METHODS: Dogs were block randomized 1:1 to placebo (saline, n = 137) or bedinvetmab (n = 135; 0.5-1.0 mg kg) administered subcutaneously, once monthly. The primary end point, day 28 Canine Brief Pain Inventory (CBPI) treatment success (TS), required pain severity score (PSS; 0-10) decrease ≥1 and pain interference score (PIS; 0-10) decrease ≥ 2. CBPI TS rates [and number needed to treat (NNT)], change in scores [and standardized effect size (ES)], change in quality of life (QoL) and bedinvetmab half-life were calculated. RESULTS: Significant (p < 0.05) improvement with bedinvetmab over placebo occurred (days 28, 42, 56, 84) for CBPI TS. Of cases evaluable for day 28 CBPI TS (placebo, n = 131; bedinvetmab, n = 128), success rates were 36.6% and 47.4%, respectively (p = 0.0410) (NNT, 9.3; PSS and PIS ES, 0.3). CBPI TS increased after the second dose in both groups, plateaued for bedinvetmab at day 42 and decreased for placebo beginning day 84. Day 84 NNT (4.3), PSS (0.4) and PIS (0.5) showed continued improvement with monthly dosing. After the first dose, mean (± standard deviation) bedinvetmab half-life was 19.1 (8.3) days. Adverse events were similar between groups and not considered treatment-related. There was a significant effect of bedinvetmab versus placebo on all CBPI components (PIS, PSS, QoL). CONCLUSIONS AND CLINICAL RELEVANCE: These results corroborated those previously reported and provide further support of safety and effectiveness of bedinvetmab (0.5-1.0 mg kg) administered subcutaneously at monthly intervals to dogs for control of osteoarthritis-related pain.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37541934/