Peer-reviewed veterinary case report
Sacubitril/valsartan effects in dogs with heart enlargement
By Newhard, Daniel K et al.·Published in Journal of veterinary internal medicine·2018·Department of Clinical Sciences·View original on PubMed →
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Original publication title: A prospective, randomized, double-blind, placebo-controlled pilot study of sacubitril/valsartan (Entresto) in dogs with cardiomegaly secondary to myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of 13 small dogs with heart enlargement due to myxomatous mitral valve disease (a common heart issue in dogs) were given either a new medication called sacubitril/valsartan or a placebo to see how it affected their heart condition. The dogs receiving the medication showed a significant decrease in a specific hormone related to heart stress compared to those on the placebo. However, overall heart function and other health markers did not show significant differences between the two groups. Fortunately, no side effects were reported in any of the dogs. This medication may offer a new way to help manage heart issues in affected dogs.
People also search for: dog heart disease treatment · sacubitril valsartan for dogs · myxomatous mitral valve disease in dogs
Abstract
BACKGROUND: The effects of sacubitril/valsartan (S/V) on the renin-angiotensin-aldosterone system (RAAS) in dogs with cardiomegaly secondary to myxomatous mitral valve disease (MMVD) are currently unknown. OBJECTIVES: To determine the pharmacodynamic effects of S/V on the RAAS, natriuretic peptide concentrations, systolic arterial pressure (SAP), tests of renal function, and serum electrolyte concentrations in dogs with cardiomegaly secondary to MMVD. ANIMALS: Thirteen client-owned dogs weighing 4-15 kg with American College of Veterinary Internal Medicine (ACVIM) Stage B2 MMVD. METHODS: Prospective, randomized, double-blind, placebo-controlled pilot study of S/V in dogs with ACVIM Stage B2 MMVD. RESULTS: Thirteen dogs were recruited: S/V (n = 7) and placebo (n = 6). The median percentage increase in urinary aldosterone to creatinine ratio (UAldo : C) between day 0 and day 30 was significantly lower in the S/V group (12%; P = .032) as compared with the placebo group (195%). The median percentage decrease of NT-proBNP concentration from day 0 to day 30 was not statistically different between groups (P = .68). No statistical differences were seen in echocardiographic, thoracic radiographic, SAP, or serum biochemical test results measured at any time point between groups. No adverse events were observed for dogs in either group. CONCLUSION AND CLINICAL IMPORTANCE: Sacubitril/valsartan may provide a new pharmaceutical method to effectively inhibit the RAAS in dogs with ACVIM Stage B2 MMVD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30084228/