Peer-reviewed veterinary case report
Does 10 mg omeprazole raise stomach acid in healthy dogs
By Gaier, Ann et al.·Published in Journal of veterinary internal medicine·2021·North Carolina State University, United States·View original on PubMed →
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Original publication title: A prospective, randomized, masked, placebo-controlled crossover study for the effect of 10 mg omeprazole capsules on gastric pH in healthy dogs.
- Species:
- dog
Plain-English summary
Six healthy dogs were given either a 10 mg omeprazole capsule, which helps reduce stomach acid, or a placebo for five days to see how well it worked. The results showed that the dogs taking omeprazole had a much higher stomach pH, meaning their stomachs were less acidic, compared to those on the placebo. This suggests that omeprazole is effective for managing stomach acid in dogs, which could be helpful for conditions like esophagitis or ulcers. If your dog has issues related to stomach acid, talk to your vet about omeprazole as a treatment option.
People also search for: dog stomach acid treatment · omeprazole for dogs · dog esophagitis symptoms
Abstract
BACKGROUND: Enteric-coated omeprazole capsules are commonly used as a gastric acid suppressant in dogs. However, the efficacy of this formulation has not been evaluated for clinical use in dogs. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of a 10 mg PO omeprazole capsule (TriviumVet) undergoing FDA approval to increase gastric pH in dogs. We hypothesized that encapsulated omeprazole would significantly increase the gastric pH compared to placebo and reach pH goals extrapolated from people for the treatment of esophagitis and duodenal ulceration. ANIMALS: Six healthy research dogs. METHODS: Randomized, blinded, 2-way crossover study. Dogs were PO administered omeprazole at 0.5 to 1.0 mg/kg or placebo (empty gelatin capsules) twice-daily for 5 days. The intragastric pH was recorded on days 2 to 5 of treatment. Mean pH and the mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were compared between and within treatment groups. RESULTS: Dogs treated with omeprazole had a significantly higher MPT ± SD intragastric pH ≥3 (91.2% ± 11.0%), ≥4 (86.9% ± 13.7%) and mean ± SD pH (5.4 ± 0.8) than dogs treated with placebo (19.7% ± 15.5%, 28.3 ± 20.7, and 2.4 ± 1.0, respectively) (P < .001 for all). CONCLUSIONS AND CLINICAL IMPORTANCE: The 10 mg enteric-coated omeprazole capsule PO administered evaluated in this study is an effective gastric acid suppressant in healthy dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33586200/