Peer-reviewed veterinary case report
How Tribrissen affects tear production in dogs
By Berger, S L et al.·Published in Journal of the American Animal Hospital Association·1995·Sacramento Animal Medical Group, United States·View original on PubMed →
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Original publication title: A quantitative study of the effects of Tribrissen on canine tear production.
- Species:
- dog
Plain-English summary
A group of dogs receiving a medication called Tribrissen (trimethoprim-sulfadiazine) for various health issues was monitored for changes in tear production. The study found that about 15% of these dogs developed a condition called keratoconjunctivitis sicca (KCS), which leads to dry eyes. This condition can cause discomfort and may require additional treatment. Pet owners should be aware of this potential side effect if their dog is prescribed Tribrissen and discuss any concerns with their veterinarian.
People also search for: dog dry eyes treatment · Tribrissen side effects in dogs · keratoconjunctivitis sicca in dogs
Abstract
The effect of trimethoprim-sulfadiazinea on Schirmer tear test (STT) values was studied in a population of dogs treated with the drug for a variety of medical and postsurgical conditions. The objectives of the study were to determine the incidence of keratoconjunctivitis sicca (KCS) secondary to trimethoprim-sulfadiazine therapy; to determine if such incidence was related to dose, duration, or both; and to identify any other factors that increased patient risk. The package insert accompanying Tribrissen states that "Dogs can tolerate up to ten times the recommended therapeutic dose without exhibiting ill effects." The results of this study indicated a 15.2% (5/33) incidence of KCS in the population of treated dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7634058/