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Peer-reviewed veterinary case report

A Quick Reference on Anion Gap and Strong Ion Gap.

Journal:
The Veterinary clinics of North America. Small animal practice
Year:
2026
Authors:
Torrente Artero, Carlos
Affiliation:
Hospital Cl&#xed · Spain

Abstract

Metabolic acid-base disorders frequently occur in emergency and critically ill patients. Recognizing these disturbances can be challenging, particularly when multiple acid-base imbalances coexist within a single patient. The anion gap (AG) and strong ion gap (SIG) are valuable calculations that help identify complex metabolic acid-base disturbances associated with unmeasured anions. This review provides definitions, reference values, indications, limitations, and guidelines for interpreting AG and SIG changes in clinical settings.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/41058323/