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Peer-reviewed veterinary case report

A Quick Reference on Hyperchloremic Metabolic Acidosis.

Journal:
The Veterinary clinics of North America. Small animal practice
Year:
2026
Authors:
Martiny, Pia M & de Morais, Helio Autran
Affiliation:
Oregon State University College of Veterinary Medicine · United States

Abstract

This article reviews hyperchloremic metabolic acidosis in small animals, a condition characterized by decreased blood pH and bicarbonate concentration, accompanied by a compensatory increase in PCO₂. Hyperchloremic metabolic acidosis arises from chloride retention, excessive sodium loss relative to chloride, or excessive chloride gain relative to sodium. Clinical manifestations are typically related to the underlying disease causing the acidosis. Management focuses on identifying and correcting the primary disorder, while alkalinizing therapy may be considered in severe or refractory cases.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/41136257/