Peer-reviewed veterinary case report
Combined oclacitinib and marine oil for dog skin allergy treatment
By Nishiyama, Takeo et al.·Published in Veterinary dermatology·2023·Aggie Animal Clinic, Japan·View original on PubMed →
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Original publication title: A randomised, double-blinded, controlled trial to determine the efficacy of combined therapy of oclacitinib and marine oil extract PCSO-524 in dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 17 dogs with atopic dermatitis (a skin condition causing itching and inflammation) was treated with a combination of oclacitinib, a common medication for allergies, and a marine oil extract called PCSO-524. Over the course of 42 days, the dogs showed significant improvement in their skin condition and reduced itching compared to those receiving only sunflower oil. The dogs receiving the PCSO-524 had better results, especially after 28 and 42 days of treatment. This combination therapy may help manage the symptoms of atopic dermatitis more effectively than oclacitinib alone.
People also search for: dog atopic dermatitis treatment · oclacitinib for dogs · marine oil extract for dog skin problems
Abstract
BACKGROUND: Polyunsaturated fatty acids (PUFA) can be beneficial in the management of canine atopic dermatitis (cAD). A commercial product PCSO-524 containing PUFA has demonstrated anti-inflammatory effects in dogs. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of PCSO-524, in combination with oclacitinib in dogs with cAD. ANIMALS: Seventeen client-owned dogs with cAD. MATERIALS AND METHODS: A randomised, double-blinded, controlled trial. All dogs were treated with oclacitinib (0.4-0.6 mg/kg) twice a day for 14 days, then once a day until Day (D)42. They were randomly divided into two groups: PCSO-524 (n = 9) and sunflower oil (n = 8). Clinical status was assessed by Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and pruritus Visual Analog Scale (pVAS) at baseline (D0), D14, D28 and D42. Trans epidermal water loss (TEWL) was measured at the same time points. RESULTS: CADESI scores decreased significantly after treatment and there was a significant difference between the PCSO-524 and the control group at D28 (p = 0.04) and D42 (p = 0.03). The PCSO-524 group also demonstrated a significantly decreased pVAS on D28 and D42 (p < 0.001 and p < 0.001) compared to D0, while significant differences were observed in the control group at D14 and D28 (p < 0.01 and p = 0.04) and not at D42 (p = 0.12). The mean TEWL showed a significant decrease at D28 and D42 in the PCSO-524 group, compared to the control group (p = 0.002 and p < 0.001). CONCLUSIONS AND CLINICAL RELEVANCE: The combination of PCSO-524 and oclacitinib may help to alleviate the rebound effect that occurs when tapering down the dosage of oclacitinib, as compared to using oclacitinib alone for the management of cAD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37485602/