Peer-reviewed veterinary case report
Interferon-gamma treatment reduces itching and skin symptoms in dogs
By Iwasaki, Toshiroh & Hasegawa, Atsuhiko·Published in Veterinary dermatology·2006·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: A randomized comparative clinical trial of recombinant canine interferon-gamma (KT-100) in atopic dogs using antihistamine as control.
- Species:
- dog
Plain-English summary
A group of 92 dogs with atopic dermatitis (a skin allergy causing itching and irritation) were treated with either a new medication called KT-100 or a common topical antihistamine for four weeks. The dogs receiving KT-100 showed much better improvement in symptoms like itching, skin redness, and hair loss compared to those using the antihistamine. Specifically, 72% of the dogs on KT-100 had reduced itching, while only 21% of the antihistamine group saw similar relief. This suggests that KT-100 may be a more effective treatment for dogs suffering from atopic dermatitis.
People also search for: dog itching treatment · atopic dermatitis in dogs · KT-100 for dog allergies · antihistamine for dog skin problems
Abstract
Recombinant canine interferon-gamma (KT-100) or topical antihistamine (diphenhydramine: DH) was administered to dogs with atopic dermatitis (AD) for 4 weeks and their efficacies were compared using pruritus, excoriation, erythema and alopecia as evaluation criteria. Clinical studies on 92 atopic dogs (KT-100 group: 63, DH group: 29) were conducted at 18 animal hospitals in Japan. KT-100 was administered subcutaneously once a day three times a week on alternating days for 4 weeks. DH was administered topically twice daily for 4 weeks. The efficacy rates of the KT-100 group on day 28 were 72.1% for pruritus, 73.8% for excoriation, 75.4% for erythema and 60.7% for alopecia, which were significantly higher than those of the DH group (20.7% for pruritus, 27.6% for excoriation, 24.1% for erythema and 24.1% for alopecia).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16674735/