Peer-reviewed veterinary case report
Intravenous lipid treatment for permethrin poisoning in cats
By Peacock, Rachel E et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2015·School of Veterinary and Life Sciences, Australia·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in cats.
- Species:
- cat
Plain-English summary
A group of 34 cats suffering from permethrin poisoning (a common insecticide) were treated with either intravenous lipid emulsion (ILE) or a saline solution to see which helped them recover faster. The cats treated with ILE showed improvement in their symptoms earlier than those receiving saline, indicating that ILE could be a helpful additional treatment for this type of poisoning. The study also developed a reliable system to assess the severity of symptoms in affected cats. Overall, ILE appears to be beneficial for cats with permethrin toxicosis.
People also search for: cat permethrin poisoning treatment · symptoms of permethrin toxicosis in cats · intravenous lipid emulsion for cats
Abstract
OBJECTIVE: To assess for any clinical benefit of intravenous lipid emulsion (ILE) for permethrin toxicosis in cats by comparing the progression of clinical signs of cats before and after treatment with ILE to cats treated with a saline control. To accomplish this objective, a clinical staging system for cats with permethrin toxicosis was developed and validated. DESIGN: Prospective, multicenter, randomized, controlled clinical trial. SETTING: University veterinary teaching hospital and 12 private veterinary emergency hospitals. ANIMALS: Thirty-four client-owned cats with permethrin toxicosis. INTERVENTIONS: A clinical staging system was designed based on abnormalities found on physical examination of cats with permethrin toxicosis. The clinical staging system had 6 stages, ranging from Stage A for cats with no abnormalities to Stage F for cats with grand mal seizures. The system was validated for intraviewer and interviewer variability. Cats in the clinical trial were randomized to receive 15 mL/kg of either intravenous 0.9% saline (control) or 20% ILE over 60 minutes. For each cat, a clinical stage was recorded at set time points before and after the randomized treatment was administered. The distribution of clinical stage stratified over time was compared across treatment groups. MEASUREMENTS AND MAIN RESULTS: The clinical staging system showed excellent repeatability (P = 1.0) and reliability (P = 1.0). In the clinical trial, there was a significant difference in the distribution of clinical stages over time (P < 0.001) and from presentation stage to Stage B (P = 0.006), with ILE-treated cats (n = 20) having lower clinical stages earlier than control cats (n = 14). There was no significant difference in signalment, body weight, or supportive treatment between the groups. CONCLUSIONS: The clinical staging system was repeatable and reliable. Clinical stages of permethrin toxicosis in ILE-treated cats improved earlier compared to control cats, suggesting ILE may be a useful adjunctive therapy in the treatment of permethrin toxicosis in cats.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26088727/