Peer-reviewed veterinary case report
How butorphanol-lidocaine and tramadol-lidocaine affect sevoflurane
By Marzok, Mohamed et al.·Published in Frontiers in veterinary science·2022·Department of Clinical Sciences·View original on PubMed →
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Original publication title: A randomized crossover study of the effect of butorphanol-lidocaine and tramadol-lidocaine on sevoflurane's minimum alveolar concentration in dogs.
- Species:
- dog
Plain-English summary
A group of 10 healthy mongrel dogs, aged 1-2 years, were studied to see how two different drug combinations could affect the amount of inhaled anesthetic (sevoflurane) needed during surgery. One group received a combination of butorphanol and lidocaine, while another group received tramadol and lidocaine. The dogs that received the butorphanol-lidocaine combination needed significantly less sevoflurane compared to those that only received sevoflurane. The tramadol-lidocaine group did not show a significant reduction in sevoflurane needs and experienced some heart rate changes. Overall, butorphanol-lidocaine appears to be a more effective option for reducing anesthetic requirements in dogs.
People also search for: dog anesthesia options · butorphanol lidocaine for dogs · tramadol lidocaine anesthesia effects
Abstract
Inhalational anesthesia is routinely used in small animal surgery. Selecting a suitable drug combination is vital since it may negatively affect the patient's physiological condition. We conducted this study to examine the sparing effect of butorphanol-lidocaine (BUT-LID) and tramadol-lidocaine (TRM-LID) on sevoflurane's minimum alveolar concentration (MAC) in 10 healthy mongrel dogs aged 1-2 years and weighing 11.5 ± 0.8 kg (mean ± SD). Sevoflurane's MAC was measured on three separate occasions. The three dog treatment groups were control (CONT) anesthetized only with sevoflurane, TRM-LID (TRM, i.v. 1.5 mg kg, then 1.3 mg kghand LID, i.v. 2 mg kg, then 3 mg kgh) or BUT-LID treatment (BUT, i.v. 0.1 mg kgthen 0.2 mg kghand LID, i.v. 2 mg kg, then 3 mg kgh). We hypothesized that both TRM-LID and BUT-LID would result in a significant MAC sparing effect in healthy dogs. The TRM-LID treatment resulted in a non-significant MAC reduction. MAC was lowered significantly in the BUT-LID group (= 0.009). The sevoflurane MAC-sparing effects of TRM-LID and BUT-LID treatments were 7.05 ± 22.20 and 19.90 ± 5.91%, respectively, a difference that was not statistically significant (= 0.13). Bradycardia was observed in the TRM-LID (< 0.001) treatment. The esophageal temperature was significantly higher for the TRM-LID treatment than the CONT (< 0.001) treatment. No statistically significant changes were detected between the three groups in, Pe'CO, and MABP. In conclusion, there was a significant sparing effect after adding BUT-LID co-infusion than the control group. No sparing effect was noticed when adding TRM-LID co-infusion. However, no difference in the MAC sparing percentages between the TRM-LID and BUT-LID treatments. The BUT-LID co-infusion resulted in a sevoflurane MAC reduction superior to TRM-LID in addition to minimal cardiorespiratory changes. Both BUT-LID and TRM-LID may be clinically beneficial to dogs during anesthesia. However, BUT-LID produced higher sparing effect and reduction of sevoflurane MAC value.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36713864/