Peer-reviewed veterinary case report
Comparing oclacitinib and Chinese herbal medicine for dog skin
By Qin, Jun-Jie et al.·Published in Research in veterinary science·2024·College of Veterinary Medicine/Traditional Chinese Veterinary Medicine, China·View original on PubMed →
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Original publication title: A randomized double-blind clinical trial: Comparison of oclacitinib with a traditional Chinese herbal medicine product (Dihuang Guiqin capsule) in the treatment of canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 60 dogs with itchy skin and rashes due to canine atopic dermatitis (cAD) were treated with either a traditional Chinese herbal medicine (Dihuang Guiqin capsule) or a common medication called oclacitinib. Over 14 days, both treatments significantly reduced itching and improved skin condition. The herbal medicine, especially at medium and high doses, worked similarly to oclacitinib and was found to be safe and well-tolerated. This herbal option could be a promising alternative for dogs suffering from cAD.
People also search for: dog itchy skin treatment · herbal medicine for dog allergies · oclacitinib side effects · canine atopic dermatitis remedies
Abstract
Canine atopic dermatitis (cAD) is a common chronic inflammatory skin disease, which seriously affects the quality of life for both dogs and their owners. Currently, the common therapeutic drugs in the clinic have disadvantages such as obvious adverse effects and high prices. Traditional Chinese herbal medicine (TCHM) has great potential for the treatment of cAD. The aim of this study is to compare the effects of different doses of the TCHM product (Dihuang Guiqin capsule) and oclacitinib in the treatment of cAD through a randomized, double-blind trial. Sixty dogs diagnosed with AD were randomly and evenly divided into four groups (n = 15). The TCHM treatment group consisted of three subgroups that received three different oral doses (20, 40, and 60 mg/kg BW), while the control group received 0.5 mg/kg BW of oclacitinib. Each group was administered twice daily for 14 consecutive days. The results showed that both TCHM and oclacitinib significantly improved cAD-induced itching (evaluated by pVAS) and skin lesions (evaluated by CADESI-04), while interleukin 31 (IL-31) concentrations decreased significantly (P < 0.05) and serum biochemical indicators returned to normal. In particular, The therapeutic effects of TCHM medium- and high-dose groups were similar to those of oclacitinib (P > 0.05). The preliminary recommended dose of Dihuang Guiqin capsule for the treatment of cAD has been determined to be 40-60 mg/kg BW twice daily for 14 consecutive days, which can be reduced to once daily as appropriate. Dihuang Guiqin capsule was safe and well tolerated, which may be a new option for the treatment of cAD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38490043/