Peer-reviewed veterinary case report
Best ciclosporin dose to treat cat skin allergies
By King, Stephen et al.·Published in Veterinary dermatology·2012·Novartis Animal Health·View original on PubMed →
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Original publication title: A randomized double-blinded placebo-controlled study to evaluate an effective ciclosporin dose for the treatment of feline hypersensitivity dermatitis.
- Species:
- cat
Plain-English summary
A group of 100 cats with skin allergies (hypersensitivity dermatitis) were treated with a medication called ciclosporin to see which dose worked best. The cats were given either a higher dose (7.0 mg/kg) or a lower dose (2.5 mg/kg), or a placebo, for six weeks. The results showed that the higher dose significantly reduced skin lesions and itching compared to the lower dose and placebo, with many cats showing over 50% improvement. Most cats tolerated the treatment well, with only mild stomach issues reported.
People also search for: cat skin allergies treatment · ciclosporin for cats · cat itching relief · feline hypersensitivity dermatitis medication
Abstract
BACKGROUND: Hypersensitivity dermatitides (HD) are frequently suspected in cats, but there are few clinical studies on safe and effective treatments in the published literature. OBJECTIVES: To establish a safe and effective dose of ciclosporin in the treatment of feline HD. ANIMALS: One hundred client-owned cats with feline HD. METHODS: Double-blind study, with cats randomly assigned to receive ciclosporin at either 7.0 mg/kg once daily (n = 33) or 2.5 mg/kg once daily (n = 32) or a placebo (n = 35) for 6 weeks. RESULTS: Mean Total Lesion Scores with 7.0 mg/kg ciclosporin were significantly lower than with 2.5 mg/kg ciclosporin (P = 0.0047) or placebo (P = 0.0003) at study end. Individual Total Lesion Scores improved by >50% in 70% of the 7.0 mg/kg group, compared with 47% in the 2.5 mg/kg group and 23% in the placebo group (P = 0.0006). The investigators' Global Assessment of Improvement was 'excellent' or 'good' in 61% of cats treated with 7.0 mg/kg ciclosporin, compared with 47% of cats given 2.5 mg/kg and 23% given placebo. The improvement in Investigator Pruritus Scores was significantly greater in cats treated with 7.0 mg/kg ciclosporin (54%) compared with both 2.5 mg/kg ciclosporin (32%; P = 0.0232) and placebo (21%; P = 0.0063). Mild gastrointestinal disorders were the most common adverse events, but these did not require cessation of therapy. CONCLUSIONS AND CLINICAL IMPORTANCE: Results suggest that 7.0 mg/kg ciclosporin once daily in food or per os for 6 weeks is effective and well tolerated in feline HD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22882582/