Peer-reviewed veterinary case report
A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.
- Journal:
- Neurobiology of disease
- Year:
- 2020
- Authors:
- Rojas, Asheebo et al.
- Affiliation:
- Department of Pharmacology · United States
- Species:
- rodent
Abstract
This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-Ereceptor EP2 with a small molecule antagonist, delayed by 2-4 h after SE onset. Administration of six doses of the selective EP2 antagonist TG6-10-1 over a 2-3 day period accelerates functional recovery, attenuates hippocampal neurodegeneration, neuroinflammation, gliosis and blood-brain barrier leakage, and prevents long-term cognitive deficits without blocking SE itself or altering acute seizure characteristics. This work has provided important information regarding organophosphate-induced seizure related pathologies in adults and revealed the effectiveness of delayed EP2 inhibition to combat these pathologies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30818067/