Peer-reviewed veterinary case report
A Recombinant Adenovirus Expressing Ovine Interferon Tau Prevents Influenza Virus-Induced Lethality in Mice.
- Journal:
- Journal of virology
- Year:
- 2016
- Authors:
- Martín, V et al.
- Affiliation:
- Centro de Investigació · Spain
- Species:
- rodent
Abstract
Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and a broad host range in vivo. We report the generation of a nonreplicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model, we showed that single-dose intranasal administration of recombinant Ad5-IFN-τ can effectively prevent lethality and disease induced by highly virulent hv-PR8 influenza virus by activating the interferon response and preventing viral replication.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26739058/