Peer-reviewed veterinary case report
A regulatory role of interleukin 15 in wound healing and mucosal infection in mice.
- Journal:
- Journal of leukocyte biology
- Year:
- 2008
- Authors:
- Kagimoto, Yoshiko et al.
- Affiliation:
- Medical Institute of Bioregulation · Japan
- Species:
- rodent
Abstract
IL-15 plays a critical role in the development and maturation of gammadelta intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-beta1 upon TCR triggering than in control mice. In vivo neutralization of TGF-beta ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-beta1, promoting wound healing but impeding protection against genital HSV-2 infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17906118/