Peer-reviewed veterinary case report
Sterile panniculitis in dogs linked to surgery and gene changes
By Yamagishi, Chie et al.·Published in The Journal of veterinary medical science·2007·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: A retrospective study and gene analysis of canine sterile panniculitis.
- Species:
- dog
Plain-English summary
A 3-year-old neutered Miniature Dachshund was diagnosed with sterile panniculitis, a skin condition that causes painful lesions and can be linked to previous surgeries or injections. The dog showed multiple skin lesions and signs of illness, which led the veterinarian to start systemic immunosuppressive therapy. This treatment was effective for most dogs, but many required ongoing therapy to prevent the condition from coming back. Surgical removal of the lesions was not usually successful in curing the problem.
People also search for: Miniature Dachshund skin problems · dog panniculitis treatment · immunosuppressive therapy for dogs
Abstract
In this study, a retrospective analysis was conducted to assess the current aspects and predisposing factors of canine sterile panniculitis. Miniature dachshund, neutered, and younger dogs appeared to be predisposed. In addition, histories of previous surgery and injection were associated in 46.5% of the cases, with several types of surgical suture materials used. About 88% of the dogs had multifocal lesions, frequently with signs of systemic illnesses. Whereas systemic immunosuppressive therapy was effective in most dogs, surgical excision of lesions was rarely curative. In order to prevent recurrences, over 65% of the cases required prolonged immunosuppressive therapy. Polymorphism of canine alpha(1)AT gene was investigated as a candidate gene for sterile panniculitis. Eight polymorphisms were discovered in seven Miniature dachshunds by direct nucleotide sequencing, which included a 12-bp deletion, three non-synonymous single nucleotide polymorphisms, and four silent substitutions. Genotyping of the two polymorphisms, c.109_120del12 and c.483A>C, which identified at high incidence in the dachshunds, was conducted in 83 dogs of 6 popular breeds. The frequencies of neither polymorphism differed between Miniature dachshunds and other breeds, suggesting that neither is responsible for developing panniculitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17917376/