Peer-reviewed veterinary case report
Differences in nasal skin disease and treatment response in dogs
By Wiemelt, S P et al.·Published in Veterinary dermatology·2004·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: A retrospective study comparing the histopathological features and response to treatment in two canine nasal dermatoses, DLE and MCP.
- Species:
- dog
Plain-English summary
A group of dogs with skin problems on their noses were diagnosed with either canine discoid lupus erythematosus (DLE) or mucocutaneous pyoderma (MCP). The study found that while both conditions showed similar skin changes under a microscope, they responded differently to treatments. Most dogs with DLE responded well to immunomodulatory therapy, while those with MCP improved with antibiotics. German shepherds were more commonly affected and often had multiple lesions. The findings suggest that even though the skin changes look alike, the treatment response can help determine the correct diagnosis.
People also search for: dog nose skin problems · canine discoid lupus treatment · mucocutaneous pyoderma in dogs
Abstract
Canine discoid lupus erythematosus (DLE) and mucocutaneous pyoderma (MCP) have overlapping clinical and histopathological changes, often making diagnosis difficult. Histopathological features of 27 nasal planum biopsies were scored to determine whether DLE and MCP were histopathologically distinguishable. Long-term follow-up, enabling assessment of clinical diagnoses, was available on 15 cases; 11/15 cases were immunomodulatory responsive (ImR) and 4/15 were antibiotic responsive (AbR). Clinical diagnosis, determined by response to treatment for 15/27 cases, was not predictable based on scoring of histopathological features. Distinct histopathological patterns were observed: 2/11 ImR cases had a lymphocyte-rich interface dermatitis. All other cases had the same histopathological changes: a band-like diffuse superficial plasmacytic to lymphoplasmacytic dermatitis +/- focal basal cell damage, but different clinical diagnoses (4/4 AbR, 9/11 ImR). German shepherd dogs/crosses were over-represented (44.4% of the cases) and tended to have more multifocal lesions (41.7% vs. 26.7% of all other breeds). Longer duration of disease was associated with a preponderance of plasmacytic infiltrate (P = 0.026).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15585008/