Peer-reviewed veterinary case report
Coronavirus infection in the central nervous system of cats and mice
By Foley, J E & Leutenegger, C·Published in Journal of veterinary internal medicine·2001·School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: A review of coronavirus infection in the central nervous system of cats and mice.
- Species:
- cat
Plain-English summary
Feline infectious peritonitis (FIP) is a serious illness that often leads to death in cats, and it can be challenging to diagnose and understand due to the wide range of symptoms and immune responses seen in affected cats. Neurological FIP, which affects the nervous system, is more consistent in its characteristics compared to other forms of FIP, making it a useful model for studying how the disease affects the immune system. Researchers suggest that studying similar infections in mice could provide valuable insights into the immune responses involved in FIP. By comparing these two diseases, scientists hope to gain a better understanding of FIP and find more effective ways to manage it. Overall, this research could lead to improved treatment options for this difficult condition.
Abstract
Feline infectious peritonitis (FIP) is a common cause of death in cats. Management of this disease has been hampered by difficulties identifying the infection and determining the immunological status of affected cats and by high variability in the clinical, pathological, and immunological characteristics of affected cats. Neurological FIP, which is much more homogeneous than systemic effusive or noneffusive FIP, appears to be a good model for establishing the basic features of FIP immunopathogenesis. Very little information is available about the immunopathogenesis of neurologic FIP, and it is reasonable to use research from the well-characterized mouse hepatitis virus (MHV) immune-mediated encephalitis system, as a template for FIP investigation, and to contrast findings from the MHV model with those of FIP. It is expected that the immunopathogenic mechanisms will have important similarities. Such comparative research may lead to better understanding of FIP immunopathogenesis and rational prospects for management of this frustrating disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11596730/