Peer-reviewed veterinary case report
How blood vessel growth affects dog skin tumor shrinking
By Costa, Diana et al.·Published in In vivo (Athens, Greece)·2020·Department of Genetics and Biotechnology·View original on PubMed →
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Original publication title: A Role for Angiogenesis in Canine Cutaneous Histiocytoma Regression: Insights into an Old Clinical Enigma.
- Species:
- dog
Plain-English summary
A dog with a cutaneous histiocytoma, a type of benign skin tumor, was observed to have spontaneous regression of the tumor over time. Researchers found that during the early stages of regression, there were fewer blood vessels in the tumor, while later stages showed an increase in new blood vessels, likely linked to the healing process. This suggests that the development of new blood vessels may play a role in how these tumors shrink and heal. Understanding this process could help veterinarians manage similar cases in the future.
People also search for: dog skin tumor treatment · canine cutaneous histiocytoma regression · why is my dog's tumor shrinking
Abstract
BACKGROUND/AIM: Canine Cutaneous Histiocytoma (CCH) is a Langerhans' cells benign tumour that undergoes spontaneous regression. The aim of the present study was to investigate the role of angiogenesis, a key step for tumour development, in CCH regression. MATERIALS AND METHODS: 50 CCH samples were classified into 4 histological groups according to a regression scale, and evaluated for expression of vascular endothelial factor-A (VEGF-A) and its receptor VEGFR-2 as well as microvessel density (MVD). RESULTS: Tumours during early stages of the regressive process had a lower MVD compared to later stages, while CCH tumoural cells showed a limited production of VEGF, but higher levels of VEGFR-2. On the contrary, tumours in advanced phases of regression showed a higher number of neovessels, probably associated with the inflammatory state and the healing process. CONCLUSION: Our results suggest that angiogenesis may be compromised at early stages of histiocytoma development and this may be a determinant of regression in this tumour.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33144434/