A series of ethyl 6-arylmethoxy-7-alkoxy-4-hydroxy-3-quinolinecarboxylates: synthesis and anticoccidial activity against Eimeria tenella.

Abstract

A series of ethyl 6-arylmethoxy-7-alkoxy-4-hydroxy-3-quinolinecarboxylates was synthesized as anticoccidial medicine, and their structures were characterized by 1H NMR, MS, and IR spectra. Anticoccidial activities of these compounds were evaluated according to the anticoccidial index method. The results indicated that five of these compounds exhibited anticoccidial activities against Eimeria tenella in the chicken's diet with a dose of 27 mg/kg. In particular, the anticoccidial index of ethyl 6-(2,5-dimethylbenzyloxy)-7-methoxy-4-hydroxy-3-quinolinecarboxylate and ethyl 6-(2,5-dimethylbenzyloxy)-7-ethoxy-4-hydroxy-3-quinolinecarboxylate was 169.3 and 175.1, respectively, which indicated that the two compounds have high anticoccidial activity.