Peer-reviewed veterinary case report
Dog with severe liver disease and myelodysplastic syndrome
By Ide, K et al.·Published in Australian veterinary journal·2003·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A severe hepatic disorder with myelodysplastic syndrome, treated with cytarabine ocfosfate, in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old female Shih Tzu was brought to the vet because she was losing weight and vomiting. Tests showed high liver enzymes and enlarged liver and spleen. Initially, the vet thought she had hepatitis and started treatment, but her symptoms didn’t improve. A liver biopsy revealed a serious condition called myelodysplastic syndrome, affecting her blood cells. After being treated with a medication called cytarabine ocfosfate, she showed signs of recovery.
People also search for: Shih Tzu vomiting treatment · dog weight loss causes · myelodysplastic syndrome in dogs · liver disease in dogs treatment
Abstract
An 8-year-old female Shih Tzu was presented with weight loss and vomiting. Alanine aminotransferase was high and abdominal radiographs revealed hepato- and splenomegaly. Mild anaemia, neutrophilia with left shift, eosinophilia, a thrombocytosis with dysplastic features of eosinophils and platelets, were detected. The animal was initially considered to have hepatitis and was treated accordingly, but clinical signs persisted. Histological examination of liver biopsy samples showed disruption of the hepatic lobule, with extensive infiltration by haemopoietic cells. Further investigation of the bone marrow suggested a diagnosis of myelodysplastic syndrome. The animal was treated with cytarabine ocfosfate, a prodrug of cytosine arabinoside, and appeared to recover.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15084010/