Peer-reviewed veterinary case report
Gene variant linked to sulfonamide allergy in Doberman Pinschers
By Reinhart, J M et al.·Published in Journal of veterinary pharmacology and therapeutics·2018·Department of Medical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A single-nucleotide polymorphism in the canine cytochrome breductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers.
- Species:
- dog
Plain-English summary
A group of Doberman Pinschers was found to have a genetic variant that may make them more sensitive to a type of medication called sulfonamides. Researchers discovered that all the Dobermans tested had a specific change in their CYB5R3 gene, which is involved in detoxifying drugs. While this genetic change was common in the breed, it didn't seem to affect how well their bodies could process the medication. This suggests that while Dobermans might be more prone to reactions from sulfonamides, the genetic variant itself may not be the direct cause.
People also search for: Doberman Pinscher sulfonamide sensitivity · dog medication reactions · genetic testing for drug sensitivity in dogs
Abstract
Canine sulfonamide hypersensitivity (HS) has been associated with a variant in the cytochrome breductase gene (CYB5R3 729A>G), which encodes a drug-detoxifying enzyme. Study objectives were to determine variant allele frequency in Doberman Pinschers (DOBE), a breed which may be predisposed to sulfonamide HS, and to characterize the effects of CYB5R3 729G on gene expression and function. CYB5R3 729A>G allele frequencies were compared between DOBE (n = 24) vs. non-Doberman (non-DOBE; n = 60) dogs. CYB5R3mRNA expression, protein expression, and reduction of sulfamethoxazole hydroxylamine were compared between banked canine liver samples of 729AA vs. GG genotype. The 729G allele was overrepresented in DOBE (1.00) vs. non-DOBE dogs (0.567, p < .0001). mRNA and protein expressions as well as cyt breductase activity were similar between livers of AA and GG genotype. All Doberman Pinschers in this study were homozygous for CYB5R3 729G, which could contribute to this breed's apparent predisposition to sulfonamide HS. However, CYB5R3 729G does not alter sulfamethoxazole detoxification capacity, so a direct role could not be demonstrated. It is possible that this marker is linked to another contributing variant.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29336038/