Peer-reviewed veterinary case report
A single residue change in Vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (Scophthalmus maximus).
- Journal:
- Journal of bacteriology
- Year:
- 2007
- Authors:
- Sun, Boguang et al.
- Affiliation:
- Department of Marine Biology · China
Abstract
Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17220231/