Peer-reviewed veterinary case report
A small heat shock protein of Ostertagia ostertagi: stage-specific expression, heat inducibility, and protection trial.
- Journal:
- The Journal of parasitology
- Year:
- 2006
- Authors:
- Vercauteren, Isabel et al.
- Affiliation:
- Faculty of Veterinary Medicine
Abstract
In this study, we isolated and analyzed a small heat shock protein (HSP) of Ostertagia ostertagi (Oo-HSP18). Oo-hsp18 is encoded by a single-copy gene and the full-length cDNA represents an 18-kDa protein. The expression of Oo-hsp18 is highly stage specific and restricted to the adult stage. The protein is synthesized in a tissue-specific manner and localized in the body muscle layer. The levels of Oo-hsp18 mRNAs are sharply induced by heat shock but not by other stressors such as levamisole and H2O2. A vaccination trial with recombinant Oo-HSP18 failed to protect calves against a challenge infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17304801/