Peer-reviewed veterinary case report
A small molecule with larger-than-expected effects on hepatitis B virus.
- Journal:
- Cell host & microbe
- Year:
- 2026
- Authors:
- Balagopal, Ashwin & Cox, Andrea L
- Affiliation:
- The Johns Hopkins University School of Medicine · United States
Abstract
Chronic hepatitis B virus (HBV) affects ∼250 million people worldwide. Functional cure is difficult to achieve with existing medications. In this issue, Fernandes et al. developed a double-humanized chronic HBV murine model to test the capsid assembly modulator GLP-26. GLP-26 reduced blood HBV DNA and surface antigen and induced immunomodulation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41539296/