Peer-reviewed veterinary case report
A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2016
- Authors:
- Lv, Guanglei et al.
- Affiliation:
- Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials · China
- Species:
- rodent
Abstract
We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Aβ oligomers both in vitro and in vivo. This probe can penetrate the blood brain barrier and specifically target Aβ oligomers in the brains of transgenic mice in models for Alzheimer's disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27346489/