Peer-reviewed veterinary case report
Genetic variants linked to chronic eye inflammation in German
By Barrientos, Laura S et al.·Published in Veterinary immunology and immunopathology·2013·Instituto de Gené·View original on PubMed →
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Original publication title: A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
- Species:
- dog
Plain-English summary
A group of German Shepherd dogs with chronic superficial keratitis (CSK), an inflammatory eye condition, was studied to understand the genetic factors that might increase the risk of developing this disease. Researchers found that certain genetic markers were significantly associated with CSK, indicating that dogs with specific gene variations were more likely to develop this eye problem. This information could help identify dogs that are at higher risk for CSK, allowing for earlier monitoring and potential treatment options.
People also search for: German Shepherd eye problems · chronic superficial keratitis in dogs · dog genetic testing for eye disease
Abstract
Canine chronic superficial keratitis (CSK) is an inflammatory corneal disease that primarily occurs in German shepherd dogs (GSDs). Several studies support the hypothesis that CSK is an immune-mediated disease. To investigate the genetic factors associated with CSK development, the upstream regulatory regions (URRs) of the DLA-DRB, -DQA and -DQB genes were genotyped in 60 dogs, including 32 CSK animals. LD analysis identified two blocks (r(2)≤45), with two DLA-DRB1 and five DLA-DQB1 haplotypes. Analysis of DLA-URR alleles/haplotypes showed a significant association between DQB1*-154 [C/T] (p=0.016) and CSK, suggesting that the T variant may increase the risk for developing CSK disease (OR=3, 95% CI=1.25-7.68). When haplotype associations were performed, the URR-DQB*CATT haplotype was significantly associated with CSK (p=0.016), increasing the risk of develop this disease over two-fold (OR=3, 95%, CI=1.25-7.68). These results showed that dogs homozygous at DRB1*69 [C/T] had a risk for developing CSK disease that was over four times the risk for heterozygotes. This genetic association supports the previous clinical, histological and pharmacological studies that suggest that CSK is an immune-mediated disease, and this association could potentially be used to identify susceptible animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24238945/