Peer-reviewed veterinary case report
Periostin's role in allergic skin disease in dogs
By Mineshige, Takayuki et al.·Published in The Journal of veterinary medical science·2018·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: A study on periostin involvement in the pathophysiology of canine atopic skin.
- Species:
- dog
Plain-English summary
A study found that dogs with atopic dermatitis (a common itchy skin condition) may have a protein called periostin that plays a key role in their skin problems. Researchers discovered that a substance called interleukin-13, which is involved in allergic reactions, can increase the production of periostin in skin cells. This suggests that periostin might help make the skin irritation worse and last longer. Understanding this could lead to better treatments for dogs suffering from atopic dermatitis, helping to relieve their itching and improve their skin health.
People also search for: dog itchy skin treatment · atopic dermatitis in dogs · periostin role in dog skin problems
Abstract
Atopic dermatitis (AD) is a chronic, pruritic, and allergic skin disease in humans and animals, particularly dogs. Canine AD (cAD) has received attention as a spontaneous atopic animal model because domesticated dogs inhabit a human environment, and cAD shares several clinicopathological features with human AD (hAD). In hAD, periostin (PO) is suggested to play a critical role in the enhancement and chronicity of allergic skin inflammation; however, PO involvement in the pathogenesis of cAD is unknown. Here we aimed to clarify PO involvement in the pathophysiology of cAD and focused on the inducing factor and function of PO in canine atopic skin. Using double-labeled in situ hybridization (ISH), interleukin (IL)-13 mRNA-positive cells were detected near the keratinocytes and dermal fibroblasts expressing PO mRNA in atopic skin. Using an in vitro assay, IL-13 induced PO gene expression in both canine dermal fibroblasts and keratinocytes. PO enhanced in vitro growth of canine keratinocytes. Moreover, among PO-induced genes in cultured canine keratinocytes detected using a microarray, we identified IL-25 as a possible mediator in canine atopic skin. In addition, real time polymerase chain reaction (PCR) analysis revealed upregulation of IL-25 gene expression in PO-stimulated keratinocytes. These data suggest that IL-13 possibly derived from T helper 2 (Th2) cells stimulates PO production in both keratinocytes and fibroblasts, and then PO may play a critical role in the pathophysiology of cAD, particularly in the enhancement and chronicity of skin lesions via IL-25.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29176263/