Peer-reviewed veterinary case report
A suicidal DNA vaccine co-expressing two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus antigens induce protective responses.
- Journal:
- Biotechnology letters
- Year:
- 2009
- Authors:
- Jiang, Yunbo et al.
- Affiliation:
- Huazhong Agricultural University · China
- Species:
- rodent
Abstract
We constructed a suicidal DNA vaccine pSFV-ORF5m/ORF6 co-expressing GP5m (a modified GP5) and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV). In mice immunization, specific immune responses were elicited by the suicidal DNA vaccine pSFV-ORF5m/ORF6. The immunogenicity and protective efficiency was then evaluated in piglets immunized with pSFV-ORF5m/ORF6 before virus challenge: PRRSV-specific neutralizing antibodies and lymphocyte proliferative responses were developed. Post-PRRSV challenge, these immune responses were further boosted and partial protection was obtained.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19116689/