Peer-reviewed veterinary case report
Poodle dog with multiple autoimmune diseases and joint swelling
By Lim, Dahye et al.·Published in Veterinary medicine and science·2022·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: A suspected case of a multiple autoimmune syndrome in a poodle dog.
- Species:
- dog
Plain-English summary
A 9-year-old male poodle was brought to the vet with yellowing of the skin and eyes (icterus), loss of appetite (anorexia), and tiredness (lethargy). He had been diagnosed with hypothyroidism and was treated with medication, but later developed severe anemia due to immune-mediated hemolytic anemia (IMHA). The vet started him on immunosuppressive drugs, which helped control the anemia, but he then experienced painful swelling in his joints. After trying different medications, including leflunomide and cyclosporine, the dog's joint pain and skin issues improved significantly.
People also search for: poodle autoimmune disease treatment · dog yellow skin and eyes · joint swelling in dogs · immune-mediated hemolytic anemia in dogs · skin problems in dogs
Abstract
A 9-year-old castrated male poodle dog was presented with icterus, anorexia, and lethargy. The dog was diagnosed with hypothyroidism 1 month before and was treated with levothyroxine. Severe anaemia with spherocytes, positive saline agglutination test, and hyperbilirubinemia indicated immune-mediated haemolytic anaemia (IMHA). Therefore, immunosuppressive therapy with prednisolone, mycophenolate mofetil, and danazol was started. Although the IMHA was well controlled, during tapering of prednisolone, acute multiple joint swelling and oedema suspected immune-mediated polyarthritis occurred twice. First, clinical symptoms improved as the dosage of prednisolone increased. However, the dog showed severe adverse effects to the steroid. Second time, we added leflunomide as another immunosuppressant, and clinical signs of arthritis disappeared. About 3 weeks later, despite the immunosuppressive therapy, skin lesions resembling an autoimmune dermatologic disorder spread throughout the body. Addition of cyclosporine resolved the skin lesions. This is a case report of a dog showing several sporadic clinical signs related to multiple autoimmune syndromes and their management using different immunosuppressant drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35137556/