Peer-reviewed veterinary case report
A Swiss Army knife for CTLs.
- Journal:
- Immunity
- Year:
- 2014
- Authors:
- Friedl, Peter & Weigelin, Bettina
- Affiliation:
- Department of Cell Biology (283) · United States
Abstract
Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. In this issue of Immunity, Prakash et al. (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic T cell diapedesis into inflamed tissue.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25526299/