Peer-reviewed veterinary case report
A virulent bioluminescent and fluorescent dual-reporter Marek's disease virus unveils an alternative spreading pathway in addition to cell-to-cell contact.
- Journal:
- Journal of virology
- Year:
- 2014
- Authors:
- Harmache, Abdallah
- Affiliation:
- Institut National de la Recherche Agronomique (INRA) · France
Abstract
Marek's disease virus (MDV) is a growing threat for the poultry industry. Unfortunately, despite successful vaccination against the disease, MDV remains in circulation within vaccinated flocks, leading to the selection of increasingly virulent pathotypes. Detailed knowledge of the virus biology and the host-virus interaction is required to improve the vaccine efficiency. In the present study, I engineered an original, dual-reporter MDV to track and quantify virus replication in vitro and in vivo.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25031355/