Peer-reviewed veterinary case report
A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention.
- Journal:
- The FEBS journal
- Year:
- 2020
- Authors:
- Oehlers, Stefan H et al.
- Affiliation:
- The University of Sydney · Australia
Abstract
Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: https://doi.org/10.1111/febs.15433.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32652856/